Basic Information
VIS ID
TVIS44007559
Fusion event
HTLV-1-NFX1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
33292518/33292520 (Hg38)
End
33292518/33292520 (Hg38)
Orient
+
Location type
Intronic
Target gene
NFX1
miRNAs that regulate target gene
hsa-mir-541-5p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-8057 ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-675-5p ; hsa-mir-4466 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267
Nearest miRNA
hsa-mir-101-2/Upstream/183755; hsa-let-7a-1/Downstream/175349;
Nearest TSS
ENST00000422679/Upstream/1975; ENST00000466359/Downstream/26501;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/1515, chr9-CpG: 41/Downstream/154928
Upstream sequence
TTGGATTTCCCTTTAGTCTGCCTTTCCCACCTGTTGGACACCTACTGTGCTGCTGTGTTATCTTGGATTTAGGGTACCACTTGTATTCTAGCCGTGGTGA
Downstream sequence
CTAGACATCCTGTTTACTAACTTCCAGCTACTTGAAATAGTGAAATAAAAATGGTGCCTCTGATCTTTGCCATGGCCAGTTTCCTGATCAATGTGTCCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate