Basic Information
VIS ID
TVIS44007566
Fusion event
HTLV-1-RGS5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
163210175/163240385 (Hg38)
End
163210175/163240385 (Hg38)
Orient
-
Location type
Intronic
Target gene
RGS5
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-181a-5p ; hsa-mir-92a-3p ; hsa-mir-20a-5p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-4635 ; hsa-mir-124-5p ; hsa-mir-4255 ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-297 ; hsa-mir-644a ; hsa-mir-6867-5p ; hsa-mir-3911 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-4749-5p ; hsa-mir-4706 ; hsa-mir-511-3p ; hsa-mir-595 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-6875-3p ; hsa-mir-6083 ; hsa-mir-6868-3p ; hsa-mir-4778-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-4446-5p ; hsa-mir-642a-5p ; hsa-mir-1290 ; hsa-mir-876-5p ; hsa-mir-3167 ; hsa-mir-6839-5p ; hsa-mir-378j ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-1243 ; hsa-mir-204-3p ; hsa-mir-7-5p ; hsa-mir-9-3p ; hsa-mir-96-3p ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-211-3p
Nearest miRNA
hsa-mir-101-1/Upstream/897745; hsa-mir-1182/Downstream/2667536;
Nearest TSS
ENST00000473358/Upstream/22749; ENST00000416401/Downstream/19465;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/417601, chr1-CpG: 52/Downstream/81304
Upstream sequence
aaaagaatagactaatagtgtatgcaaaaacataaataagtctcaaaaacacagtaaacaaacaaagccttaccaaaagaatgtatactctatggtttca
Downstream sequence
ttcatatgaagttctagaatgggtggaactaattcatggtggggaaaaaaaaaaaaactagaccatatgcatcaggaggcagggtggagattgactggaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate