Basic Information
VIS ID
TVIS44007577
Fusion event
HTLV-1-ARNTL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
13308946/13287399 (Hg38)
End
13308946/13287399 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARNTL
miRNAs that regulate target gene
hsa-mir-494-3p ; hsa-mir-142-3p ; hsa-mir-335-5p ; hsa-mir-3674 ; hsa-mir-6844 ; hsa-mir-6073 ; hsa-mir-6505-3p ; hsa-mir-4280 ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-513a-5p ; hsa-mir-3607-3p ; hsa-mir-4494 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p
Nearest miRNA
hsa-mir-210/Upstream/1123632; hsa-let-7a-2/Downstream/2682134;
Nearest TSS
ENST00000527297/Upstream/9514; ENST00000485918/Downstream/22587;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/8353, chr11-CpG: 82/Downstream/175327
Nearest cancer related gene
ARNTL(TSG, No orient, 0)
Upstream sequence
ctatTTGGTCAGTTGTGAATGGTGTGTTCCTTTTTTTCCTTACTTGAAGGCATAGCGAGGAGTTGGTACAAGAAGTTATTGCTTCATGGACTTCACTTTG
Downstream sequence
GAGCTAGAGGGTGGCATTAGACCTAGCCTGCCTTCTTGGATGCTGGAATACCAGTGGCAAtgtcatctcttgttctctgctatacccctagcaatgaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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