Basic Information
VIS ID
TVIS44007583
Fusion event
HTLV-1-MED13L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
116685443/116247638 (Hg38)
End
116685443/116247638 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
MED13L
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-328-3p ; hsa-mir-23b-3p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-676-5p ; hsa-mir-582-3p
Nearest miRNA
hsa-let-7i/Upstream/98984; hsa-mir-1178/Downstream/180614;
Nearest TSS
ENST00000382841/Upstream/238493; ENST00000548506/Downstream/29121;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/330256, chr12-CpG: 196/Downstream/29012
Upstream sequence
GCCATAGCTATGTTGCTGGCCAAGGATTCCCTGTGTAGATGGGCTGCTGACGAGACACTGGGCCTCCCATCTGACTGGTTATTTCCATGTTATGAGAAAT
Downstream sequence
ACAATGTGGTATTCCTCCATACAATGAGGTCATATATAAAAGATGCTAACGTATATATATATACACACACATATGCATATGTGCTGATTCATAAATGTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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