Basic Information
VIS ID
TVIS44007584
Fusion event
HTLV-1-chr12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
128183038/127698493 (Hg38)
End
128183038/127698493 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12E
Nearest miRNA
hsa-let-7i/Upstream/2782834; hsa-mir-3612/Downstream/595599;
Nearest TSS
ENST00000382841/Upstream/62026; ENST00000536342/Downstream/122690;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/242131, chr12-CpG: 18/Downstream/62554
Upstream sequence
GATTTCAGTAGGGGAGATGTGTTTAAAAGGTGTTGATTTGGTCTGTAAAAGACTTCAAAATGGCTTGTAAAACTGAGATAGAAATAGCACGGCAATGAGG
Downstream sequence
AATATGCTTTGAAACAGCTTCCAGTGGGTTGTAGTTTAGCTCAGCCCCAAAAGCTATTCATAGCCTGTAGTGAAGCTCCATCTTTAAAATACATCTCCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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