Basic Information
VIS ID
TVIS44007585
Fusion event
HTLV-1-PDS5B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
33329373/32755235 (Hg38)
End
33329373/32755235 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDS5B
miRNAs that regulate target gene
hsa-mir-27a-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-2276/Upstream/8592731; hsa-mir-1267/Downstream/6908799;
Nearest TSS
ENST00000623511/Upstream/54251; ENST00000447833/Downstream/2934;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/167537, chr13-CpG: 157/Downstream/260555
Nearest cancer related gene
PDS5B(TSG, No orient, 0)
Upstream sequence
ATTTATATTTTTATTTGGCAAATAGGAAATATAAATGGAAATTGTCCAGAATATGAGTCCCAGTCTATGTGTACCCCTTATTAAACCAATTAGGATTACC
Downstream sequence
ATTCTGACCTCTTTAACAGAATATGTTTATCTCAGCCAACATACAAAAATAATTGCATTTAAACTAAATAGCTGTTTCTTTATTTAAAATGCCCTAGAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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