Basic Information
VIS ID
TVIS44007601
Fusion event
HTLV-1-WDR72 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
53905938/53613741 (Hg38)
End
53905938/53613741 (Hg38)
Orient
-
Location type
Exonic
Target gene
WDR72
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-297 ; hsa-mir-5590-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4719 ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-10393/Upstream/1336541; hsa-mir-11181/Downstream/1759199;
Nearest TSS
ENST00000557528/Upstream/72638; ENST00000561210/Downstream/70886;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/807462, chr15-CpG: 33/Downstream/145717
Upstream sequence
TATCTGTGCCAGTAACTCTCTTACCATTTCGTAAGCAACTGTAGAAGCTTGACATATTTAAAATGTCATTCCCAGCACCTCTCATCTTATTATGTATACT
Downstream sequence
TTCCATTCTGAAAGAACTGTTAGAAAAAAGATTGACAGCATATTACTAAAAAGCATGAAAAATTATTTGAGGAAATAAATCAAAGATATGGGTACATGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate