Basic Information
VIS ID
TVIS44007604
Fusion event
HTLV-1-FLYWCH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2946278/2896277 (Hg38)
End
2946278/2896277 (Hg38)
Orient
-
Location type
Intronic
Target gene
FLYWCH2
miRNAs that regulate target gene
hsa-mir-548s ; hsa-mir-4684-5p ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-3675-3p ; hsa-mir-6771-3p ; hsa-mir-4738-3p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4485-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-106a-3p ; hsa-mir-7641 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3622b-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-4695-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-5197-5p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-203a-3p ; hsa-mir-6788-3p ; hsa-mir-193b-5p ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-4635 ; hsa-mir-3663-5p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-483-5p ; hsa-mir-3124-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-5193 ; hsa-mir-4707-5p
Nearest miRNA
hsa-mir-1225/Upstream/364272; hsa-mir-11401/Downstream/589104;
Nearest TSS
ENST00000527434/Upstream/13018; ENST00000572786/Downstream/2478;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1600, chr16-CpG: 116/Downstream/7913
Upstream sequence
aaggctgccaggagaggaactggcagagcagaagcctagttccatcaggccccctgTCAGTCTTGGCCCCAGCGAGCAGTGAGGCAGCCCCATCTGCCCC
Downstream sequence
ACCTCCCTCCCAGATCCACGTCTAGAGCCTCCCAAGGGCTTCCACCACTGACGGGATTTTGCTTCCTTCCTTAGGACGGAACCGCTGGACTCCAGGTTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate