Basic Information
VIS ID
TVIS44007622
Fusion event
HTLV-1-CWC22 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
180814235/179949508 (Hg38)
End
180814235/179949508 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
CWC22
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-484
Nearest miRNA
hsa-mir-10b/Upstream/88600; hsa-mir-1244-1/Downstream/1356085;
Nearest TSS
ENST00000437798/Upstream/88003; ENST00000629145/Downstream/57545;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/87770, chr2-CpG: 21/Downstream/57392
Upstream sequence
ataatggataaaatggcatttaacttctctagttgaaatgcaaattaaaactaaaaccgccatgcagtaccattacacatccaccagaatggctgaaatg
Downstream sequence
aaaaagacggtcaatttgaagtattaatgagaatgggagctaatgaaactcttatacatggccggtgggagtgtaaataggaataaccacttggaaaact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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