Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene4463400144668547447376814468430144687671446760194467832644667002446692014466357444665714446384154464032344648142446497904465814444659534446830364468422644671236446724084465308944653498446610614466125044685841
Basic Information
VIS ID
TVIS44007629
Fusion event
HTLV-1-PRR5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
45081721/44685841 (Hg38)
End
45081721/44685841 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
PRR5
miRNAs that regulate target gene
hsa-mir-1292-5p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-1281/Upstream/2762544; hsa-let-7a-3/Downstream/515113;
Nearest TSS
ENST00000624155/Upstream/8707; ENST00000403696/Downstream/16357;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/16629, chr22-CpG: 101/Downstream/16034
Nearest cancer related gene
PRR5(TSG, No orient, 0)
Upstream sequence
GTTGCTCAGAACTTCTACACAGAATCCCAAGCACCAAGGGTGGGGCTGGAATCAAAGCCGAGATACGTGATGCCCCTTCCGCCTAACTTTGTCCCCTTCT
Downstream sequence
AACCCAGATAGTGCCCAGAAAGATGGTTCCACTTGCAGGCCCTGTGCCCAGGGCCCTGGCTTCCGTGGTACCATCCTTTCTCCCTGGGGGAGCACCGTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate