Basic Information
VIS ID
TVIS44007630
Fusion event
HTLV-1-CNTN4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p26.3
Reference genome
GRCh37/hg19
Start
2516939/2475255 (Hg38)
End
2516939/2475255 (Hg38)
Orient
+
Location type
Intronic
Target gene
CNTN4
miRNAs that regulate target gene
hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4504 ; hsa-mir-661 ; hsa-mir-873-3p ; hsa-mir-6776-5p ; hsa-mir-6742-3p ; hsa-mir-6827-3p ; hsa-mir-340-3p ; hsa-mir-5586-3p
Nearest miRNA
hsa-let-7g/Downstream/2774922;
Nearest TSS
ENST00000440867/Upstream/236426; ENST00000480113/Downstream/36095;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/375155, chr3-CpG: 95/Downstream/651385
Upstream sequence
GGTACGAAATGGACAAAAAGGATTTTAAAGTTGTATCTGGGGTGGGAAATATGTCTCAAAACACTTGGAGATAACTGCTATCATGTTGAGGAAGAAGTCC
Downstream sequence
GTTCAAAGAAGAAAAGGATGCCATTTGTTTTACTTAGTTCTTTAAACTAAAGCACTAACCTCTTTTACACCAAAGTTAATATCCCCTTTATAAACTCTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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