Basic Information
VIS ID
TVIS44007637
Fusion event
HTLV-1-NEPRO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
112733752/113014905 (Hg38)
End
112733752/113014905 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEPRO
miRNAs that regulate target gene
hsa-mir-28-3p ; hsa-mir-4451 ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-4650-3p ; hsa-mir-3614-5p ; hsa-mir-1255b-2-3p
Nearest miRNA
hsa-let-7g/Upstream/277724; hsa-mir-12124/Downstream/417213;
Nearest TSS
ENST00000440867/Upstream/3369; ENST00000470313/Downstream/4255;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/23482, chr3-CpG: 48/Downstream/4492
Upstream sequence
TTATGTTCCTCTGCATCTTCTCTCTTTCTCCCTTCTCTCTCTTGGGTTTTTTTTCTCTTTTGAACCGCAGTTCACTTACTATGTTTTCCAAGTGCTTTAC
Downstream sequence
CATCTGGgtttgtcaatacctccctcaaaggatggtgtccagacttgaaaactgaaaaagataggagctgaccctaaagaatttaaggattgttccctcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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