Basic Information
VIS ID
TVIS44007651
Fusion event
HTLV-1-FBXL17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
107251894/107916193 (Hg38)
End
107251894/107916193 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
FBXL17
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-186-3p ; hsa-mir-548p ; hsa-mir-548b-3p ; hsa-mir-330-3p
Nearest miRNA
hsa-mir-10397/Upstream/7099628; hsa-mir-103a-1/Downstream/2597636;
Nearest TSS
ENST00000502646/Upstream/199352; ENST00000513676/Downstream/448574;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/243703, chr5-CpG: 220/Downstream/464415
Upstream sequence
ACCTTACCTAAGCCACTGCTAGGCAGTGTACATGGTGCAGTAAACATAAAGTCCAGATCCCCAGTGTTATGTCCATATTTATTCAATAAAGACTAGGTGG
Downstream sequence
TTTGGGACTACGATAATCAATCCTTTGTTTTCACAAGGTTTTATGAAATGTAAGGCCATCTAAACATGGTTAAGGTCATGCTTTTAAAGTCTAAAACAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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