Basic Information
VIS ID
TVIS44007662
Fusion event
HTLV-1-AUTS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
69065293/69600307 (Hg38)
End
69065293/69600307 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
AUTS2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/2485910; hsa-mir-10399/Downstream/1707365;
Nearest TSS
ENST00000635602/Upstream/432; ENST00000476695/Downstream/42996;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/256, chr7-CpG: 64/Downstream/995541
Upstream sequence
CTGCACCCCCTCCACAGCAGATGGGCAGAAAGAAAGGGGTTCGGGCATCACAACAATGCGCCCCCTCTCCACAGAGAGCTCTGCCCCCACTCCTTCCTCC
Downstream sequence
TCTCCCTCCCCAATCATGGCTTCTTGGCTGGTGGAAGTCTCTTTGCTGGGTTTGGGGCGCCTGTGGACGGTTCTGTGTGCTTTCTACAGAGTCATATGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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