Basic Information
VIS ID
TVIS44007666
Fusion event
HTLV-1-COG5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
107162438/107521993 (Hg38)
End
107162438/107521993 (Hg38)
Orient
-
Location type
Intronic
Target gene
COG5
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-320a ; hsa-mir-3978 ; hsa-mir-4261 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-610 ; hsa-mir-181a-2-3p ; hsa-mir-497-3p
Nearest miRNA
hsa-mir-10525/Upstream/5050462; hsa-mir-10399/Downstream/7131352;
Nearest TSS
ENST00000635602/Upstream/41051; ENST00000467916/Downstream/26339;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/352109, chr7-CpG: 59/Downstream/41676
Upstream sequence
aacgatagattggataaagaaaatgtgctacacacaccatgcagccataaaaaaaaatgaaatcatgtccttggcagggacatggatgaagctggaagcc
Downstream sequence
ttcatcctcagcaaactagcacaggaatagaaaaccaaacactgcacattctcactcgtaaatgggagttgaacaacgagaacacttggacacagggagg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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