Basic Information
VIS ID
TVIS44007683
Fusion event
HTLV-1-MTMR8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
63615203/64395323 (Hg38)
End
63615203/64395323 (Hg38)
Orient
+
Location type
Intronic
Target gene
MTMR8
Nearest miRNA
hsa-let-7f-2/Upstream/609236; hsa-mir-105-1/Downstream/1623547;
Nearest TSS
ENST00000429181/Upstream/45283; ENST00000617377/Downstream/108;
Nearest CpG islands
chrX-CpG: 34/Target, None/Upstream, None/Downstream
Upstream sequence
CCACAGGAAAGACGCGTCAAAGAAGGCTGAGAAGGCTGAGGAGGTGTGTCTGGGCTCCCAGGTGAGCACCAAGAGGAAGCTCGCGGCTGTCAGCCTCGCT
Downstream sequence
TAACTCTTCTCCTTACCTTGGGTACCGTAATATGATCCATGACTGCAGTTCCCGCCACCGGAAGATCTCAGTGCTACTCCAGATGCCGCCGCCACCGGTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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