Basic Information
VIS ID
TVIS44007688
Fusion event
HTLV-1-ATP1A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
116922688/116380066 (Hg38)
End
116922688/116380066 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP1A1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-340-5p ; hsa-mir-26b-5p ; hsa-mir-93-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-23b-3p ; hsa-mir-30d-5p ; hsa-mir-197-3p ; hsa-mir-196a-5p ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-26a-5p ; hsa-mir-18a-5p ; hsa-let-7b-5p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-155-3p ; hsa-mir-3160-5p ; hsa-mir-4746-3p ; hsa-mir-3124-3p ; hsa-mir-1250-5p ; hsa-mir-6753-5p ; hsa-mir-1911-3p
Nearest miRNA
hsa-mir-101-1/Upstream/3497937; hsa-mir-1182/Downstream/179958;
Nearest TSS
ENST00000473358/Upstream/6199; ENST00000463382/Downstream/2345;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/5875, chr1-CpG: 44/Downstream/38494
Upstream sequence
CGAAATGGGCTGCATTTGGGGCACTTCCTTTTGCCATCCTTCTGGCCCTTCTTGCCCGTCAAAAGCTTTTGTCTGTGGGCTTTGGAAATAGTCCAGTTTT
Downstream sequence
TAAGGTGTTTTATTTTTCAGAGTTAATGGTTTCTTGACTAATCAGACTATGAAAATGCCTTCTCTAGGTTCTTTAATAGTTATACCAAGtgttattccca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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