Basic Information
VIS ID
TVIS44007690
Fusion event
HTLV-1-TRIM8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
104407952/102648195 (Hg38)
End
104407952/102648195 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
TRIM8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-7-5p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-126-5p ; hsa-mir-656-3p ; hsa-mir-889-3p ; hsa-mir-4477a ; hsa-mir-4795-3p ; hsa-mir-6885-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-3140-3p ; hsa-mir-130b-5p ; hsa-mir-182-5p
Nearest miRNA
hsa-mir-107/Upstream/211611; hsa-mir-1307/Downstream/746058;
Nearest TSS
ENST00000439456/Upstream/2498; ENST00000642304/Downstream/1017;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2984, chr10-CpG: 45/Downstream/8603
Nearest cancer related gene
TRIM8(OG, No orient, 0)
Upstream sequence
CCTAGATCCTAAATGTGCTCTCCCATGAGGCTGTGGGGAAGCTAAGGGCCCAAGATTTGGACATCCAGGTGGGCTCAGGCCTGGCAGTCCTGAGTGGTCA
Downstream sequence
GACCCCTCCTAGCCCCCAGGTTCAGGGGTTCATCTAAGCATTGAAGGACTGGTGGGAGCTGGGGGGCATCCTTATCTCATGACCCCCCATGACATGGAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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