Basic Information
VIS ID
TVIS44007706
Fusion event
HTLV-1-GPR158 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
25497657/25208728 (Hg38)
End
25497657/25208728 (Hg38)
Orient
+
Location type
Intronic
Target gene
GPR158
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-4666a-5p ; hsa-mir-4772-3p ; hsa-mir-4699-3p ; hsa-mir-944 ; hsa-mir-629-3p ; hsa-mir-374a-3p ; hsa-mir-136-5p ; hsa-mir-1266-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p
Nearest miRNA
hsa-mir-1265/Upstream/932947; hsa-mir-107/Downstream/3080530;
Nearest TSS
ENST00000439456/Upstream/32452; ENST00000482641/Downstream/257462;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/32018, chr10-CpG: 96/Downstream/725264
Upstream sequence
CAGAGAGAAGCACTGGAACTGTGTCACATTGTGCTGGCAGCAAGAACATCTCGACATTTCCCGACCACATGGTGGCCTCTACAAACTGTCAAATTAGGTA
Downstream sequence
GGTCCCAAACCTGCTTTCACCTGAATTAACCTGCAAACCCACTAGAGCACAGGTTTGGGATTACTTGGAGACTGTACAGGAGAGCAGGTCACTTCCTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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