Basic Information
VIS ID
TVIS44007712
Fusion event
HTLV-1-EPHA6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
96770565/97051721 (Hg38)
End
96770565/97051721 (Hg38)
Orient
+
Location type
Intronic
Target gene
EPHA6
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-216b-5p ; hsa-mir-3675-3p ; hsa-mir-4290 ; hsa-mir-4667-3p ; hsa-mir-4691-5p ; hsa-mir-4762-5p ; hsa-mir-5193 ; hsa-mir-519d-5p ; hsa-mir-520f-5p ; hsa-mir-6779-3p ; hsa-mir-6792-3p
Nearest miRNA
hsa-let-7g/Upstream/691682; hsa-mir-12124/Downstream/2912593;
Nearest TSS
ENST00000440867/Upstream/236930; ENST00000503760/Downstream/387889;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/236940, chr3-CpG: 38/Downstream/712575
Upstream sequence
actcatttgatgttagatatgtacccccaaagttACATGATAAGTGTTGCAGTAGTTTTCAGGAGGAAGATTGCTTCTAGTTAATTCTgtggttctcaat
Downstream sequence
cttggcttcacacaggaattagttggaaggcttcactgatgtttaggtctcaccctcagagattctgatataattgttccagattgcagcctggacaCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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