Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene6382586362248591629996526301507963039171630076156301154963013068630146816302410563025704630243726302529463032800630329876302237763022462630120226301203163037227
Basic Information
VIS ID
TVIS44007718
Fusion event
HTLV-1-GGH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
63949786/63037227 (Hg38)
End
63949786/63037227 (Hg38)
Orient
-
Location type
Intronic
Target gene
GGH
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-124-1/Upstream/1322368; hsa-mir-10400/Downstream/1341922;
Nearest TSS
ENST00000518652/Upstream/7011; ENST00000522282/Downstream/1574;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/787722, chr8-CpG: 91/Downstream/1336
Upstream sequence
gtattcccagcttcttacaattggcattcatcaggtattcaGATTAACATGTCAAACGCCAAAATTTGTTCAGTAAAACTTTTTCTCCTTACTGGTAGGT
Downstream sequence
AAGATCATCTTCACTAAGGAATAACAAAGTTTGGCTAGGGAACGAAGAACTAGGAGTGTCATAGGAAATGGAGTGGTACAGGGTACATGGGGTGAGGTAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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