Basic Information
VIS ID
TVIS44007730
Fusion event
HTLV-1-SCYL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
169852717/169883576 (Hg38)
End
169852717/169883576 (Hg38)
Orient
-
Location type
Intronic
Target gene
SCYL3
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-6516-5p ; hsa-mir-6809-3p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-4753-3p ; hsa-mir-3119 ; hsa-mir-3622b-5p ; hsa-mir-130b-5p ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-5009-3p ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-1197 ; hsa-mir-3613-3p ; hsa-mir-371a-5p ; hsa-mir-371b-5p ; hsa-mir-372-5p ; hsa-mir-373-5p ; hsa-mir-4703-3p ; hsa-mir-616-5p ; hsa-mir-6500-3p ; hsa-mir-8080 ; hsa-mir-1292-5p ; hsa-mir-1294 ; hsa-mir-142-3p ; hsa-mir-1-5p ; hsa-mir-202-5p ; hsa-mir-2681-5p ; hsa-mir-3591-5p ; hsa-mir-4316 ; hsa-mir-4471 ; hsa-mir-450a-1-3p ; hsa-mir-4796-5p ; hsa-mir-5689 ; hsa-mir-586 ; hsa-mir-648 ; hsa-mir-654-3p ; hsa-mir-8059 ; hsa-mir-890
Nearest miRNA
hsa-mir-101-1/Upstream/1507955; hsa-mir-1182/Downstream/267802;
Nearest TSS
ENST00000473358/Upstream/87655; ENST00000440321/Downstream/5312;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/88370, chr1-CpG: 66/Downstream/9738
Upstream sequence
ATTGGGAGGAGAGTGATGAAATATTTCATTTGGAAGATAACCCTCAATATATTACCAGGTGGCATTTTCATAAATAAGCAGTGAATACTGAACACCTTCT
Downstream sequence
TGGAGGACTATGGGCTAGCATAAGAATCCATACCCTGCATTGGTATAATTTTTGTATCAGATGCCTCAAACTTTATTAAACTACTTCCAGGCAGGGTCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate