Basic Information
VIS ID
TVIS44007734
Fusion event
HTLV-1-ZNF37A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
38391362/38102434 (Hg38)
End
38391362/38102434 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF37A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-539-5p ; hsa-mir-578 ; hsa-mir-580-3p ; hsa-mir-526b-5p ; hsa-mir-1299 ; hsa-mir-5093 ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-335-3p ; hsa-mir-4639-5p ; hsa-mir-5007-3p
Nearest miRNA
hsa-mir-1265/Upstream/2461182; hsa-mir-107/Downstream/4895129;
Nearest TSS
ENST00000439456/Upstream/5860; ENST00000608335/Downstream/34903;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/7400, chr10-CpG: 41/Downstream/253750
Upstream sequence
cattatttacctagtgttaatacttggaattgcaattaacatcttgaatttataacaatctagcttgcattaataccaactaagccttaatattatataa
Downstream sequence
aaactctgctcctatacagctttgtccctgtcttttgtcttcttattgtcacatattaggccttcataaattgtgtgcacattacatagatgcataatta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate