Basic Information
VIS ID
TVIS44007737
Fusion event
HTLV-1-ADK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
76316376/74556618 (Hg38)
End
76316376/74556618 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADK
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-5571-5p ; hsa-mir-4674 ; hsa-mir-6878-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-4437 ; hsa-mir-4757-5p ; hsa-mir-6744-3p ; hsa-mir-378g ; hsa-mir-4680-5p ; hsa-mir-532-3p ; hsa-mir-212-5p ; hsa-mir-6513-3p ; hsa-mir-1224-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-6813-3p ; hsa-mir-498 ; hsa-mir-592 ; hsa-mir-4279 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-597-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1914-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-1265/Upstream/1835518; hsa-mir-107/Downstream/995840;
Nearest TSS
ENST00000439456/Upstream/26065; ENST00000604130/Downstream/265512;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/379388, chr10-CpG: 35/Downstream/256819
Upstream sequence
GTTGTATATTTAGCCATAGATTGTCTATGGAATAGCAGTGCCACTTAGAAGATTGGTGGGAGAGGCATATATAGCATTCATGGACACATTTTCTAAGTCT
Downstream sequence
TACTGAGCAATTCTTAACCAATCTTAGCTTTTCTCCTACTGTCTCCCTTAATGTTTCAAGTTTTTAAAAATATAGGACTCTGTTTTAGAATTTGAGGAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate