Basic Information
VIS ID
TVIS44007739
Fusion event
HTLV-1-PWWP2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
134216439/132402935 (Hg38)
End
134216439/132402935 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PWWP2B
Nearest miRNA
hsa-mir-107/Upstream/1440267; hsa-mir-202/Downstream/844576;
Nearest TSS
ENST00000439456/Upstream/5767; ENST00000428814/Downstream/16148;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5375, chr10-CpG: 136/Downstream/1829
Upstream sequence
cgtataaaggaacctgggggctgtgctgtgtgctagtaaaactttcttcacaaacgctggagcggccaggtgtggcccgctggccCCCGGGGTGCATGGG
Downstream sequence
GTCTGTGCTCCTCGGTCCTGGCGCCAGCACCTGGCTGGGACTGGTGAGGGCACCGCCCGGGACTGGCCTCCCTTTCTCGCGAAAGTCTTAGCCCATCAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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