VISDB - VIS Detail

Basic Information

VIS ID

TVIS44007742

Fusion event

HTLV-1-PTPRJ integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr11

Cytoband

p11.2

Reference genome

GRCh37/hg19

Start

48081011/48059459 (Hg38)

End

48081011/48059459 (Hg38)

Orient

Location type

Intronic

Target gene

PTPRJ

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-328-3p ; hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-31-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-205-5p ; hsa-mir-92b-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-548c-3p ; hsa-mir-1277-5p ; hsa-mir-592 ; hsa-mir-376a-5p ; hsa-mir-4672 ; hsa-mir-597-5p ; hsa-mir-376a-2-5p ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-936 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-6768-5p ; hsa-mir-4789-5p ; hsa-mir-3591-5p ; hsa-mir-190a-3p ; hsa-mir-142-3p ; hsa-mir-27b-5p ; hsa-mir-4280 ; hsa-mir-6516-3p ; hsa-mir-627-3p ; hsa-mir-3149 ; hsa-mir-1303 ; hsa-mir-5007-5p ; hsa-mir-505-3p ; hsa-mir-2278 ; hsa-mir-27a-5p ; hsa-mir-28-5p ; hsa-mir-299-3p ; hsa-mir-3139 ; hsa-mir-3158-3p ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-3688-5p ; hsa-mir-4265 ; hsa-mir-4266 ; hsa-mir-4296 ; hsa-mir-4322 ; hsa-mir-4417 ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-548au-3p ; hsa-mir-6132 ; hsa-mir-6501-3p ; hsa-mir-6510-5p ; hsa-mir-6721-5p ; hsa-mir-6836-5p ; hsa-mir-708-5p ; hsa-mir-7106-3p ; hsa-mir-891a-3p

Nearest miRNA

hsa-mir-129-2/Upstream/658417; hsa-let-7a-2/Downstream/37323;

Nearest TSS

ENST00000527297/Upstream/14655; ENST00000527026/Downstream/85619;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/77841, chr11-CpG: 17/Downstream/820686

Nearest cancer related gene

PTPRJ(TSG, No orient, 0)

Upstream sequence

tgatccacctgccttggcctcccaaagtgctgggattacaggcgtgagccactgcgcctggctgctctgctttttacccatagctctggctctaatatat

Downstream sequence

gacactgcccctccctgaattagaatggaggctacagggggatgctggtctgttagttgactgatgcatcttcagcacttaagacagtgtctggcacaga

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.