Basic Information
VIS ID
TVIS44007792
Fusion event
HTLV-1-SPOPL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
139260597/138503027 (Hg38)
End
139260597/138503027 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
SPOPL
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-324-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-3150b-3p ; hsa-mir-4784 ; hsa-mir-5689 ; hsa-mir-138-2-3p ; hsa-mir-548c-3p ; hsa-mir-675-3p ; hsa-mir-205-3p ; hsa-mir-3662 ; hsa-mir-493-5p ; hsa-mir-218-5p ; hsa-mir-6746-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-3975 ; hsa-mir-6770-5p ; hsa-mir-4695-5p ; hsa-mir-2278 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-1252-3p ; hsa-mir-3941 ; hsa-mir-4708-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-3180-5p ; hsa-mir-6844 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-6794-3p ; hsa-mir-29a-5p ; hsa-mir-4639-3p
Nearest miRNA
hsa-mir-128-1/Upstream/2837549; hsa-mir-10b/Downstream/2083599;
Nearest TSS
ENST00000437798/Upstream/1095; ENST00000467775/Downstream/47130;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/685, chr2-CpG: 96/Downstream/277095
Upstream sequence
TTTCCTGACTGAACTCTGTCATTCAGTGATTCTTTCCAGGCTTCTGATGCTTTGTCTATTTTTGAATAATCTTGGGCCTAGTTTGACCCATTGTGGTACT
Downstream sequence
CACTTTCCCACTTGCAATTGAATCCACTGTTTCTTGGACTAGAAACTGACAGAGGTAAAAGGTTCATACCTTGAAAAATTACATCTCTCCTGCCACGATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate