Basic Information
VIS ID
TVIS44007797
Fusion event
HTLV-1-LOC646736 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
227008045/226143329 (Hg38)
End
227008045/226143329 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LOC646736
Nearest miRNA
hsa-mir-10b/Upstream/1132789; hsa-mir-1244-1/Downstream/515381;
Nearest TSS
ENST00000437798/Upstream/444815; ENST00000607970/Downstream/42042;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/560314, chr2-CpG: 74/Downstream/647858
Upstream sequence
ATTTTCTCTTCACAGCCCAGAGCTCTGACTATGGTTTAGCACCTTCCACGGGGTGAGAGGAAGTTAGATAAATTGGAATTTGTTTCCTGTTCCCATGTGA
Downstream sequence
ACTGCTACATCTGTGCATGACTCTCCAGAATATTTACTTATTTTTATAGATTTTGTCCATGCTTATGTTTATAAAACAGATGTGTTAATTGAATTTTTTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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