Basic Information
VIS ID
TVIS44007803
Fusion event
HTLV-1-CLASP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
33585561/33544069 (Hg38)
End
33585561/33544069 (Hg38)
Orient
-
Location type
Intronic
Target gene
CLASP2
miRNAs that regulate target gene
hsa-mir-210-3p
Nearest miRNA
hsa-mir-12127/Upstream/1037680; hsa-let-7g/Downstream/2200407;
Nearest TSS
ENST00000440867/Upstream/8621; ENST00000430877/Downstream/1042;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/102697, chr3-CpG: 86/Downstream/173645
Upstream sequence
TTAAAAAGATGACTGACTCTGGTTCACAAGAAATTGTTTTAGAATTACTTTTAACCCTCCTCAGACTTTACCTTAAGCCTGCCATCAGTGTGTCTCCTTT
Downstream sequence
ATTTGCCATTAAATGTCTTTCTTTTTAATGCTTCAGTTCAATTCTTTAGGCATATAATGTAAGTTATTTCATACCAGTAAAAAatatatatatgtataca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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