VISDB - VIS Detail

Basic Information

VIS ID

TVIS44007825

Fusion event

HTLV-1-MCC integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr5

Cytoband

q22.2

Reference genome

GRCh37/hg19

Start

112579119/113243422 (Hg38)

End

112579119/113243422 (Hg38)

Orient

Location type

Intronic

Target gene

MCC

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-494-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-219b-5p ; hsa-mir-3973 ; hsa-mir-5692a ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-2355-5p ; hsa-mir-1306-5p ; hsa-mir-4687-5p ; hsa-mir-548aw ; hsa-mir-4451 ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-6716-5p ; hsa-mir-4650-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-4790-3p ; hsa-mir-548aj-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-301b-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-19b-3p ; hsa-mir-19a-3p

Nearest miRNA

hsa-mir-10397/Upstream/2729507; hsa-mir-103a-1/Downstream/3012321;

Nearest TSS

ENST00000502646/Upstream/8745; ENST00000416046/Downstream/51516;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/266113, chr5-CpG: 37/Downstream/51100

Nearest cancer related gene

MCC(OG, No orient, 0)

Upstream sequence

CACAGGGCAACAAAGCTTCGGCAGCTATAGGATACTACTTGTGAGTATCCTATACTCCTATACTCCAGGTCTCTGCCTTAACCCTTCACACGTACAGGAC

Downstream sequence

TACTGTCTCTCACCTTGACCACATTCCCTAAAAGAACAGAGAACTCTGTAGTATGAATACCACAGACCTCAGTTACTACAGGCTTTGACTGAAAGAATAA

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.