Basic Information
VIS ID
TVIS44007833
Fusion event
HTLV-1-PDE7B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
136361534/136040396 (Hg38)
End
136361534/136040396 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDE7B
miRNAs that regulate target gene
hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-7106-5p ; hsa-mir-149-3p ; hsa-mir-4736 ; hsa-mir-766-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-6715b-3p ; hsa-mir-4717-3p ; hsa-mir-6715a-3p
Nearest miRNA
hsa-mir-10398/Upstream/801140; hsa-mir-1202/Downstream/2394817;
Nearest TSS
ENST00000381078/Upstream/2105; ENST00000446774/Downstream/24242;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/542374, chr6-CpG: 51/Downstream/209586
Upstream sequence
TCCTGTGCCTCCTCACTCTCAGGGAGATGAGGGCTCATCCTTACTGGAATGGGCATAAAACCTTTTCATCATCATCCATCTATGCAGCAGCAGGTCATAG
Downstream sequence
GATGCAACCCCAAAGATGAGTGGCTTCACTTTCCAAACTGTCTCTTACCTTCTTCCTTACTCATCCTATTCCTGATGCTGCATTTCCTCTGAGCATCAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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