Basic Information
VIS ID
TVIS44007838
Fusion event
HTLV-1-DLGAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
1436328/1488162 (Hg38)
End
1436328/1488162 (Hg38)
Orient
-
Location type
Intronic
Target gene
DLGAP2
miRNAs that regulate target gene
hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-20a-3p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-4764-5p ; hsa-mir-627-3p ; hsa-mir-4635
Nearest miRNA
hsa-mir-10400/Downstream/312963;
Nearest TSS
ENST00000518652/Upstream/110295; ENST00000522499/Downstream/13204;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/5004, chr8-CpG: 25/Downstream/4333
Nearby gene
DLGAP2(+13204) ;
Upstream sequence
TTCCTCAGCAGTTTCAAGCTGTGGCATATTCTTCAGGATTTCTTGACAAGCCCACTCAGGGCAGAGCCTCCGTTGAACAGCCAGGTGGGAGGCTGGGAGT
Downstream sequence
CCTTCTtccacacagtcctccccacactgtcctccacacagtcctccacCCCCCTGCAAACTCCCACCCGGCAGTTCACAGAGAGGCCTCATCTCCCAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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