Basic Information
VIS ID
TVIS44007858
Fusion event
HTLV-1-RERE integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.23
Reference genome
GRCh37/hg19
Start
8416275/8356215 (Hg38)
End
8416275/8356215 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA1A
Target gene
RERE
miRNAs that regulate target gene
hsa-mir-200b-3p ; hsa-mir-429 ; hsa-mir-92b-3p ; hsa-mir-301a-3p ; hsa-mir-320a ; hsa-mir-4681 ; hsa-mir-4722-3p ; hsa-mir-4763-5p ; hsa-mir-4769-3p ; hsa-mir-596 ; hsa-mir-6501-3p ; hsa-mir-6727-3p ; hsa-mir-6817-5p
Nearest miRNA
hsa-mir-12136/Upstream/1926319; hsa-mir-101-1/Downstream/510287;
Nearest TSS
ENST00000473358/Upstream/1133; ENST00000444276/Downstream/6629;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/12173, chr1-CpG: 18/Downstream/2047
Nearest cancer related gene
RERE(OG, No orient, 0)
Upstream sequence
AAGCATCTCGTGCTCGTGTGGGGGCTGTCCAAGCAGAGGGTTGGGGAGAGTGCCAGGCGGGTAGGGGAAGCGAGCCAGGTGGGGACCGGCAGTCAGGGGG
Downstream sequence
TCGACCAGCGGGTGAACGGGGCCTGCTGAACCTAAGGAAAGGACAAAACGCCAGATGGAGGCGGTGTGCAGCTCTTCAATGTTTGTCCCCCTTGGCTGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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