Basic Information
VIS ID
TVIS44007871
Fusion event
HTLV-1-H2AFY2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
71814678/70054922 (Hg38)
End
71814678/70054922 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
H2AFY2
miRNAs that regulate target gene
hsa-mir-769-5p
Nearest miRNA
hsa-mir-1265/Upstream/2651512; hsa-mir-107/Downstream/1735825;
Nearest TSS
ENST00000439456/Upstream/2042; ENST00000373218/Downstream/63429;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/985, chr10-CpG: 71/Downstream/77414
Upstream sequence
TCATAACCCCTCTTTCCTGTAGCCAAATTTCCTTTTAAAACATGCCCAGTTCTCCTCTTCTCTGGTTTTTCCTATCCTACCACAGTTACACCTCACCTGG
Downstream sequence
ATCCATTAATTGTCAGACTTTACACATTATTAGTGGTTTCCTCTATATCAAAACTGCGTAAAAGAATTTACCTCCTTGAATCCGGAGTGTCCCTGTGATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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