Basic Information
VIS ID
TVIS44007873
Fusion event
HTLV-1-C10orf90 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
128285115/126596546 (Hg38)
End
128285115/126596546 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
C10orf90
Nearest miRNA
hsa-mir-107/Upstream/776724; hsa-mir-202/Downstream/3246753;
Nearest TSS
ENST00000439456/Upstream/71723; ENST00000473861/Downstream/73900;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/91584, chr10-CpG: 171/Downstream/308494
Nearby gene
C10orf90(No orient, 75105)
Upstream sequence
ctagcaatagacttgtacctgttacatacgcttcttcacttatgatggggttacatcctgacaaatctattgtaagttgaaaatattctaagtcaaaaat
Downstream sequence
gcatttaattcacccaacctagcaaacatcaaagcttagcctagcctactttcaatgtactcagaacacttacattagcctacagttgtgcagagtcatc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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