Basic Information
VIS ID
TVIS44007875
Fusion event
HTLV-1-ADGRA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
134914101/133100597 (Hg38)
End
134914101/133100597 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ADGRA1
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-107/Upstream/2137929; hsa-mir-202/Downstream/146914;
Nearest TSS
ENST00000439456/Upstream/12106; ENST00000392606/Downstream/1649;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/62, chr10-CpG: 17/Downstream/4654
Upstream sequence
GCTCCTGGGGCCCAGGCCTGCGGTGACAGCTCGGGGCGGATGCTGGGGTGTTGGGGCTGCAGCAGGCAGGTCTGGAAGGTTCCAGAGGGTTGCAATCTTG
Downstream sequence
GAGGAGATCTTGTTAAGGCAACAGCCATCAGGAGGAAATGAGCAGAAAAGATTGTGGCCTATCTCCAGATGCTGTCCTGATCTCCCAGGGAGCACGATCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate