Basic Information
VIS ID
TVIS44007876
Fusion event
HTLV-1-OSBPL5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
3163970/3142740 (Hg38)
End
3163970/3142740 (Hg38)
Orient
-
Location type
Intronic
Target gene
OSBPL5
miRNAs that regulate target gene
hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-744-5p ; hsa-mir-1539 ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-449b-3p
Nearest miRNA
hsa-mir-210/Upstream/969602; hsa-let-7a-2/Downstream/713322;
Nearest TSS
ENST00000527297/Upstream/13411; ENST00000455154/Downstream/18653;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/22093, chr11-CpG: 42/Downstream/17604
Upstream sequence
CAGGACCGCTGGTTTCATGTCTCTGTCTCTCCTCATAGACCCACTCAGGTGGAGACCTGTCCCTCTGTCTCCGTGTCCGCGGGGCCCGGCAGGAAGTCGT
Downstream sequence
GTGCAGGGGTGGAGGCTGGAAGACCAGCAGGTCTCCCTTCACCTGGGGATCCCCGAGCCCCATGCAGCCTTGCGGGTAGAAGGGCAGTGACTGCCCACTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate