Basic Information
VIS ID
TVIS44007877
Fusion event
HTLV-1-PLEKHA7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
16967022/16945475 (Hg38)
End
16967022/16945475 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
PLEKHA7
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-210/Upstream/975854; hsa-let-7a-2/Downstream/1442312;
Nearest TSS
ENST00000527297/Upstream/63856; ENST00000620945/Downstream/67867;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/19624, chr11-CpG: 169/Downstream/67821
Upstream sequence
TTTACTGTGTTGGCCTACCCTTCACACAGGTGTCTCTCCTCTGTGATTTCACAACCCCtgtaattgactgttgtctgccttccccaaaagactgagagtt
Downstream sequence
ccttaaggacaATACCTCTTCACAAAGTCCTGTAGTGCTTGGTAAGGGATgatggatagatggacagatggacagatggatgAAAGCCTGAAGGGCAGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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