VISDB - VIS Detail

Basic Information

VIS ID

TVIS44007878

Fusion event

HTLV-1-NAV2 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr11

Cytoband

p15.1

Reference genome

GRCh37/hg19

Start

20113011/20091465 (Hg38)

End

20113011/20091465 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA11C ; FRA11I

Target gene

NAV2

miRNAs that regulate target gene

hsa-mir-663a ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-3202 ; hsa-mir-3179 ; hsa-mir-6876-5p ; hsa-mir-4779 ; hsa-mir-4476 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6835-3p ; hsa-mir-4668-5p ; hsa-mir-1298-5p ; hsa-mir-664a-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6759-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-2117 ; hsa-mir-6793-5p ; hsa-mir-6748-5p ; hsa-mir-597-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-299-3p ; hsa-mir-6818-3p ; hsa-mir-6888-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3120-5p ; hsa-mir-335-3p ; hsa-mir-664b-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-627-3p

Nearest miRNA

hsa-mir-210/Upstream/331382; hsa-let-7a-2/Downstream/3327640;

Nearest TSS

ENST00000527297/Upstream/42162; ENST00000525025/Downstream/12746;

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/314062, chr11-CpG: 96/Downstream/64597

Upstream sequence

CCAGATGGAGTCGCTGACTGCCCCCTTTGCATCCTTGGAAATTCCTCTTTCATATTGTTCCCTCCACTGGGTATATTCCTCTGCACATCCAAGTTAGACC

Downstream sequence

CTTCCCTTAATGCTCGGCCTGATTCCTTTCCAAGTCTTGCAGCTGGAGAGTTAGTACCCTTATCTGAGTATTCCTGTAGATTTGTTCTTACAGCCCCTCC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.