Basic Information
VIS ID
TVIS44007885
Fusion event
HTLV-1-chr11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76301164/76590120 (Hg38)
End
76301164/76590120 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/1254934; hsa-let-7a-2/Downstream/2811902;
Nearest TSS
ENST00000527297/Upstream/44172; ENST00000447519/Downstream/36714;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/144337, chr11-CpG: 92/Downstream/80285
Nearby gene
EMSY(No orient, 37221)
Nearest cancer related gene
EMSY(OG, No orient, 37221)
Upstream sequence
gataaaatgcacacacatgggggcatttagcaaagcccctggccaatatgcggggctcaaGCTGGGACTCAGCTCCTGTTGGGAGCCGGCAGTCAGCCCT
Downstream sequence
GGAGCACGGGGCTGAGGCCCGGGTTGCTGACAACCCCCTGCCCTCCACTGCTCTGAGGCCTCTTGCAGCTAAGAGAGCCAAGGAGGAGGGGCAGGGAGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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