Basic Information
VIS ID
TVIS44007903
Fusion event
HTLV-1-MYH11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
15844330/15750473 (Hg38)
End
15844330/15750473 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16A
Target gene
MYH11
miRNAs that regulate target gene
hsa-mir-887-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-4472 ; hsa-mir-6848-5p ; hsa-mir-4447 ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6781-5p ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-1296-3p ; hsa-mir-660-5p ; hsa-mir-744-3p ; hsa-mir-106a-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-593-3p ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-1322 ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-1182
Nearest miRNA
hsa-mir-1225/Upstream/107101; hsa-mir-11401/Downstream/549686;
Nearest TSS
ENST00000527434/Upstream/8282; ENST00000573856/Downstream/28950;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/99907, chr16-CpG: 44/Downstream/106509
Upstream sequence
ACCCCTAAATAGGCCAGAGGCTCAGCCCCAGCCCCACCCACCAACCTGCCCACTCCAATCTTTCCTTCCATCACCAACGCCTCCTTCGGCAGTCAGGGTT
Downstream sequence
TCCAAGTATTGTCTATTGGGGAAATCCTGAGAGCACCTGAgtggcagaaagaacaaattccctgtgatggagtcacgctgacctaggagtcaagcctgct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate