Basic Information
VIS ID
TVIS44007914
Fusion event
HTLV-1-BCAS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
58981013/60903652 (Hg38)
End
58981013/60903652 (Hg38)
Orient
-
Location type
Intronic
Target gene
BCAS3
miRNAs that regulate target gene
hsa-mir-1278 ; hsa-mir-1285-3p ; hsa-mir-2861 ; hsa-mir-3187-5p ; hsa-mir-326 ; hsa-mir-330-5p ; hsa-mir-3664-5p ; hsa-mir-3667-3p ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-4714-5p ; hsa-mir-514a-5p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-6734-3p ; hsa-mir-6860 ; hsa-mir-6883-3p
Nearest miRNA
hsa-mir-10226/Upstream/860547; hsa-mir-1250/Downstream/2040563;
Nearest TSS
ENST00000595228/Upstream/13891; ENST00000590352/Downstream/83205;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/225533, chr17-CpG: 720/Downstream/492047
Upstream sequence
aacacccacctcagccttccaagtagctgggactacgggcgcatgccgccacgcctggtttgtagagacagggttttgccatgttacgcaggctggtctt
Downstream sequence
gaacttctgagcttaagcaatccacccacctcagcctcccaaagtgctggggttacaggtgtgcatcaccgcacccagcAATTGCAGAAATCTTAATAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate