Basic Information
VIS ID
TVIS44007915
Fusion event
HTLV-1-ICAM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
10389974/10279298 (Hg38)
End
10389974/10279298 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ICAM1
miRNAs that regulate target gene
hsa-mir-17-3p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-31-5p ; hsa-mir-17-5p ; hsa-mir-155-5p ; hsa-mir-1256 ; hsa-mir-21-5p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-296-3p ; hsa-mir-146a-5p ; hsa-mir-485-5p ; hsa-mir-6884-5p ; hsa-mir-93-5p ; hsa-mir-324-3p ; hsa-mir-3941 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-3188 ; hsa-mir-2467-5p ; hsa-mir-3975 ; hsa-mir-3186-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-466 ; hsa-mir-4643 ; hsa-mir-92b-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-141-5p
Nearest miRNA
hsa-mir-1227/Upstream/48813; hsa-let-7e/Downstream/124160;
Nearest TSS
ENST00000633603/Upstream/8178; ENST00000585443/Downstream/2960;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8009, chr19-CpG: 80/Downstream/7629
Upstream sequence
caaaagttgggagcagggagaaatcttgatggaggcaggaggaggaggaggtaggttggtgtaggccaggtgcagtggctcacacctgtaatcccagtgc
Downstream sequence
tttgggaggccaaagcaagaggattgtttgagcccaggagttcgagaccagcctgggcaacatagcgagaccctgtctctaagaaaaaataaaaaaatta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate