Basic Information
VIS ID
TVIS44007926
Fusion event
HTLV-1-TSN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
122524322/121766746 (Hg38)
End
122524322/121766746 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA2S
Target gene
TSN
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-93-5p ; hsa-mir-221-3p ; hsa-mir-653-5p ; hsa-mir-671-5p ; hsa-mir-4742-5p ; hsa-mir-4772-5p ; hsa-mir-34c-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-432-3p ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-548au-3p ; hsa-mir-3925-5p ; hsa-mir-589-5p ; hsa-mir-7849-3p ; hsa-mir-4692 ; hsa-mir-383-5p ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269
Nearest miRNA
hsa-mir-1285-2/Upstream/8045378; hsa-mir-10b/Downstream/5656791;
Nearest TSS
ENST00000437798/Upstream/10575; ENST00000422649/Downstream/23698;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/10796, chr2-CpG: 79/Downstream/2257929
Upstream sequence
CTCTTGCTATTGAATTGAGATGATTAAAATGGTGACTTAATCCGTAGTTATTTTGCACCCACTGAAAGGAAAGTGCTTTCCAGAATAATATGAAGTATCT
Downstream sequence
AAAAGTGTCACCTTTTCTTGCCTGATCAACAATTTGGGCTTCCTGTTTGTACAAGGGGCCATTTGGCATACCTTTCACAGCTTTTATCAGGCCAAGTTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate