Basic Information
VIS ID
TVIS44007950
Fusion event
HTLV-1-PARL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
183557560/183839772 (Hg38)
End
183557560/183839772 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
PARL
miRNAs that regulate target gene
hsa-mir-1301-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-25-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4686 ; hsa-mir-8485 ; hsa-mir-3925-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-3152-5p ; hsa-mir-6836-3p ; hsa-mir-452-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-3912-3p
Nearest miRNA
hsa-let-7g/Upstream/7324621; hsa-mir-1224/Downstream/47028;
Nearest TSS
ENST00000440867/Upstream/14178; ENST00000422946/Downstream/2582;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/13756, chr3-CpG: 37/Downstream/44872
Upstream sequence
cctcccaaagtgctgggattacaggtgtgagccactgcacccagccTCAAAACACACTTAAAAAAAAAttttttttttgagatagggtcttgctatgtca
Downstream sequence
cccaggctggggtgcagtggtacaatcacagctcaccgcagcctcaacctcctaggctcaagctatcctccttcctcagcctcctgagtagctgagacta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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