Basic Information
VIS ID
TVIS44007960
Fusion event
HTLV-1-WDR70 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
37648738/37648636 (Hg38)
End
37648738/37648636 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
WDR70
miRNAs that regulate target gene
hsa-mir-6844 ; hsa-mir-6873-3p ; hsa-mir-9-5p ; hsa-mir-4778-3p ; hsa-mir-7152-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-660-3p ; hsa-mir-5193
Nearest miRNA
hsa-mir-10397/Upstream/1500648; hsa-mir-103a-1/Downstream/908866;
Nearest TSS
ENST00000502646/Upstream/169166; ENST00000508730/Downstream/74007;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/269082, chr5-CpG: 51/Downstream/185933
Upstream sequence
TCTTGGTAGTTCAGTTGTTAGAAGTCACTGTAAAATAACACCAACAAACATGGTTTTTACCAATCTTGTGCCATCTGGAATTTATGGATAAAAATTGTGG
Downstream sequence
TTGGGGACATATCTTTGGCTTTAGATAAAACAACACTGTCAAGTTGAGTACTTCCCACTTCTTTGTAGTTTGTTGTTCATAGGATTTTGAATTATGGCTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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