Basic Information
VIS ID
TVIS44007964
Fusion event
HTLV-1-ATG10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
81289526/81993707 (Hg38)
End
81289526/81993707 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATG10
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-215-5p ; hsa-mir-181a-5p ; hsa-mir-192-5p ; hsa-mir-6794-3p ; hsa-mir-342-3p ; hsa-mir-4639-3p ; hsa-mir-216b-3p ; hsa-mir-3680-5p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-653-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-3919 ; hsa-mir-4756-3p ; hsa-mir-382-5p ; hsa-mir-7850-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-3941 ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-10397/Upstream/9115044; hsa-mir-103a-1/Downstream/846448;
Nearest TSS
ENST00000502646/Upstream/6149; ENST00000508814/Downstream/79995;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/21159, chr5-CpG: 49/Downstream/284307
Upstream sequence
agtagagatggggtttcacgatgttggtcaggctggtctcaaactcctgacctcgtgatccgcctgccttggcttcccaaagtactgggattacagacgt
Downstream sequence
gagccaccgtgcccagccTTAGCCTGGTTTCTGACACATAGAAAGCTGTGTCAGAATTTTTAGTTAGTTGTTTGAAAATTTCAGTGTCTTTTATTATAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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