Basic Information
VIS ID
TVIS44007977
Fusion event
HTLV-1-CHN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
29407745/29368129 (Hg38)
End
29407745/29368129 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHN2
Nearest miRNA
hsa-mir-1183/Upstream/2198566; hsa-mir-10399/Downstream/312605;
Nearest TSS
ENST00000635602/Upstream/32422; ENST00000491856/Downstream/28519;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/172699, chr7-CpG: 17/Downstream/195364
Upstream sequence
GAATTGTCAGCACTATGTAGAGAGTGGAGGGATTTCAGGTTTCCTGGGAGTTGATTTCTATTAACATTTGTTGGAGTGTCAAAAAATTTAACATCTTCAT
Downstream sequence
AATCTATATTTTGACATCAGACATTATTTAAAAAATACTAACAAACCAACTTGGACTCAGATGTCTCATATTTTTAACCATTGCCGAGACAAATTAAACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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