Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene504040665059006350793462504584365056545750553955505615955056223250567624505775615057948650591086505923395059830950599287505926325059353350584954505855575058893050589414505801645058031350598764
Basic Information
VIS ID
TVIS44007979
Fusion event
HTLV-1-GRB10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
50666461/50598764 (Hg38)
End
50666461/50598764 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRB10
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-877-5p ; hsa-mir-222-3p ; hsa-mir-199b-5p ; hsa-mir-548aw ; hsa-mir-504-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3613-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-4433b-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-130a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-570-3p ; hsa-mir-221-3p ; hsa-mir-1253 ; hsa-mir-298 ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-302e ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-4311 ; hsa-mir-4477a ; hsa-mir-4678 ; hsa-mir-519a-3p ; hsa-mir-519b-3p ; hsa-mir-519c-3p ; hsa-mir-520a-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-520d-3p ; hsa-mir-520e
Nearest miRNA
hsa-mir-1183/Upstream/5716964; hsa-mir-10399/Downstream/6357021;
Nearest TSS
ENST00000635602/Upstream/2924; ENST00000420449/Downstream/7649;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/130509, chr7-CpG: 120/Downstream/183291
Upstream sequence
cacacagccagtcatggaggagTTCCTGGTTCAGCAGGAAAAGCAGACGAAAAGTGAAAGTATCCCTCTTACAAGGGTGCTATGTGAGTCCTGGGGATAA
Downstream sequence
CACCTCTCTTTCTGCGGTTGGGAGAAGGGAAAGCTTCAAAGAATTCAAATTTTGCCGAAGAGGTTTCCTTCCAACAtgtggaggggcatgaagtgcagac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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