Basic Information
VIS ID
TVIS44007985
Fusion event
HTLV-1-UBR5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103421743/102409515 (Hg38)
End
103421743/102409515 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
UBR5
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-1-3p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-331-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-20b-5p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-12123/Upstream/284000; hsa-mir-10400/Downstream/745099;
Nearest TSS
ENST00000518652/Upstream/48306; ENST00000523572/Downstream/3174;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/169667, chr8-CpG: 122/Downstream/2302
Upstream sequence
GTAAAGAAAGAAAACGTATTTGAAGAAAACACTACTGTTTTGAGGACCAAGTTTTCTTCAGCTGAGCAATTTATTTGCAGTACCATTCTGCCTGTCTAAT
Downstream sequence
CTTACTACTTTTATTCCAAAGTATAAAGTCTATTTACACCCTTTTCATACATAACTATGATTATCATTTTATTTGTGACTCTCATACATTTCTCATAATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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